Margaret C Frame Selected Research

PLX 4720

4/2015

FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling.

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Margaret C Frame Research Topics

Disease

49	Neoplasms (Cancer) 05/2024 - 06/2002
10	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2023 - 02/2009
8	Neoplasm Metastasis (Metastasis) 01/2023 - 01/2005
8	Colonic Neoplasms (Colon Cancer) 09/2008 - 08/2002
6	Carcinogenesis 01/2023 - 02/2009
4	Breast Neoplasms (Breast Cancer) 01/2023 - 01/2012
3	Carcinoma (Carcinomatosis) 12/2014 - 02/2005
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2023 - 11/2022
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 08/2013
2	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 06/2011
2	Cicatrix (Scar) 01/2013 - 01/2006
2	autosomal recessive 1 Spinocerebellar ataxia 01/2006 - 12/2004
1	Adenocarcinoma of Lung 01/2023
1	Brain Neoplasms (Brain Tumor) 01/2021
1	Inflammation (Inflammations) 01/2021
1	Melanoma (Melanoma, Malignant) 04/2015
1	Astrocytoma (Pilocytic Astrocytoma) 06/2011
1	Adenocarcinoma 07/2010
1	Disease Progression 07/2010
1	Wounds and Injuries (Trauma) 06/2010
1	Papilloma (Papillomatosis) 02/2009
1	Gliosis 07/2007
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 05/2007

Drug/Important Bio-Agent (IBA)

21	Focal Adhesion Protein-Tyrosine KinasesIBA 07/2022 - 12/2004
15	Proteins (Proteins, Gene)FDA Link 01/2023 - 12/2004
11	Phosphotransferases (Kinase)IBA 05/2024 - 06/2002
10	IntegrinsIBA 01/2023 - 08/2002
8	src-Family KinasesIBA 01/2016 - 06/2004
6	Cadherins (E-Cadherin)IBA 01/2013 - 08/2002
5	CytokinesIBA 01/2023 - 08/2010
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 07/2014 - 10/2004
3	Dasatinib (BMS 354825)FDA Link 08/2013 - 12/2006
3	Biomarkers (Surrogate Marker)IBA 08/2010 - 12/2006
2	Interleukin-33IBA 01/2021 - 12/2017
2	ChemokinesIBA 04/2016 - 09/2015
2	Actin-Related Protein 2-3 Complex (Arp2 3 Complex)IBA 01/2013 - 01/2006
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2012 - 01/2011
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 06/2011 - 06/2007
2	CalpainIBA 05/2011 - 12/2002
2	Phosphatidylinositols (Phosphatidylinositol)IBA 06/2007 - 05/2007
2	LipidsIBA 06/2007 - 05/2007
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2024
1	Interleukin-6 (Interleukin 6)IBA 01/2023
1	ProteomeIBA 01/2023
1	5'- O- (9- phenylxanthen- 9- yl)- 2'- deoxynebularineIBA 01/2023
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2023
1	Toll-Like Receptor 2IBA 11/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	ChromatinIBA 01/2021
1	Histone Deacetylase InhibitorsIBA 01/2020
1	Chemokine CCL5IBA 12/2017
1	Insulin-Like Growth Factor Binding Protein 3IBA 10/2017
1	PND 1186IBA 09/2015
1	AntigensIBA 09/2015
1	LigandsIBA 09/2015
1	PLX 4720IBA 04/2015
1	Cre recombinaseIBA 02/2012
1	matriptaseIBA 01/2012
1	Fluorescent Dyes (Fluorescent Probes)IBA 07/2011
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 07/2011
1	TransducinIBA 06/2011
1	Leucine-Rich Repeat ProteinsIBA 06/2011
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 06/2011
1	CateninsIBA 06/2011
1	TalinIBA 05/2011
1	calpain inhibitorsIBA 05/2011
1	erythromycin propionate-N-acetylcysteinateIBA 01/2011
1	AgarIBA 10/2010
1	Transforming Growth Factor beta (TGF-beta)IBA 08/2010
1	CarcinogensIBA 08/2010
1	GelsIBA 06/2010
1	Mutant Proteins (Protein, Mutant)IBA 06/2010
1	anthraceneIBA 02/2009
1	saracatinibIBA 02/2009
1	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)IBA 10/2008
1	Actins (F Actin)IBA 09/2007
1	Chondroitin Sulfate ProteoglycansIBA 07/2007
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 07/2007
1	Glial Fibrillary Acidic ProteinIBA 07/2007
1	Heparin (Liquaemin)FDA LinkGeneric 07/2007
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 06/2007
1	Phosphodiesterase 4 InhibitorsIBA 06/2007
1	RolipramIBA 06/2007
1	ColforsinIBA 06/2007
1	cilostamideIBA 06/2007
1	Cyclic AMP (AMP, Cyclic)IBA 06/2007
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 06/2007
1	Adenylyl Cyclases (Adenylyl Cyclase)IBA 06/2007
1	Phosphodiesterase 3 InhibitorsIBA 06/2007
1	TensinsIBA 06/2007
1	Growth Factor ReceptorsIBA 05/2007
1	PaxillinIBA 12/2006
1	Phospho-Specific AntibodiesIBA 12/2006
1	Tyrosine (L-Tyrosine)FDA Link 01/2006
1	afimoxifene (hydroxytamoxifen)IBA 12/2004
1	Irinotecan (Camptosar)FDA LinkGeneric 10/2004

Therapy/Procedure

6	Therapeutics 01/2023 - 08/2010
1	Immunotherapy 01/2021
1	Drug Therapy (Chemotherapy) 10/2004